Effects of Caffeine mixed with Alpha Lipoic Acid in Preventing Streptozotocin-induced Diabetes in Rats: In Silico and In vivo Study

Objective: This study aimed to investigate the combined effects of caffeine and Alpha Lipoic Acid (ALA) on oxidative stress, due chronic hyperglycemia, in a model diabetic rats induced with streptozotocin (STZ) (in silico vivo approaches). Material Methods: In investigated interaction between ALA against insulin receptors enzymes Glutathione Peroksidase-1 (GPx-1), molecular docking. Male, Wistar were included using quasi-experimental research design, post-test only control group vivo). measured end result 6-week-induction body weight, fasting blood glucose, Malondialdehyde (MDA) GPx-1 enzyme from 25 rats. Results: Molecular docking found interactions consisting an energy bond -5,06 kcal/mol, hydrogen hydrophobic bond. Additionally, it showed containing -5.16 bonding hydrophobicity. However, there no significant difference MDA levels ALA-caffeinated compared rats.Conclusion: Caffeine have potential activate study). use combination resulted glucose stress conditions when without additional induction